Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors LR Comstock, SR Rajski Nucleic acids research 33 (5), 1644-1652, 2005 | 79 | 2005 |
Conversion of Aryl Azides to O-Alkyl Imidates via Modified Staudinger Ligation JA Restituyo, LR Comstock, SG Petersen, T Stringfellow, SR Rajski Organic Letters 5 (23), 4357-4360, 2003 | 59 | 2003 |
Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3 A Kasamatsu, M Nakao, BC Smith, LR Comstock, T Ono, J Kato, JM Denu, ... Journal of Biological Chemistry 286 (24), 21110-21117, 2011 | 49 | 2011 |
Methyltransferase-directed DNA strand scission LR Comstock, SR Rajski Journal of the American Chemical Society 127 (41), 14136-14137, 2005 | 47 | 2005 |
Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs LR Comstock, JM Denu Organic & Biomolecular Chemistry 5 (19), 3087-3091, 2007 | 29 | 2007 |
Fluorescent DNA Labeling by N‐Mustard Analogues of S‐Adenosyl‐L‐Methionine Y Du, CE Hendrick, KS Frye, LR Comstock ChemBioChem 13 (15), 2225-2233, 2012 | 28 | 2012 |
N-mustard analogs of S-adenosyl-L-methionine as biochemical probes of protein arginine methylation SJH Bergman, LR Comstock Bioorganic & medicinal chemistry 23 (15), 5050-5055, 2015 | 27 | 2015 |
Synthesis of an Azide-Bearing N-Mustard Analogue of S-Adenosyl-l-methionine V Mai, LR Comstock The Journal of Organic Chemistry 76 (24), 10319-10324, 2011 | 25 | 2011 |
Efficient synthesis of azide-bearing cofactor mimics LR Comstock, SR Rajski The Journal of Organic Chemistry 69 (4), 1425-1428, 2004 | 23 | 2004 |
Expeditious synthesis of aziridine-based cofactor mimics LR Comstock, SR Rajski Tetrahedron 58 (30), 6019-6026, 2002 | 23 | 2002 |
Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-l-methionine M Ramadan, NK Bremner-Hay, SA Carlson, LR Comstock Tetrahedron 70 (34), 5291-5297, 2014 | 20 | 2014 |
50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA ZT Laughlin, S Nandi, D Dey, N Zelinskaya, MA Witek, P Srinivas, ... Proceedings of the National Academy of Sciences 119 (14), e2120352119, 2022 | 10 | 2022 |
Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use SR Rajski, LR Comstock, RL Weller US Patent 7,465,544, 2008 | 9 | 2008 |
Protein Arginine Methyltransferase 1‐Dependent Labeling and Isolation of Histone H4 through N‐Mustard Analogues of S‐Adenosyl‐l‐methionine SJ Hymbaugh, LM Pecor, CM Tracy, LR Comstock ChemBioChem 20 (3), 379-384, 2019 | 7 | 2019 |
O-acetyl-ADP-ribose non-hydrolyzable analogs JM Denu, LR Comstock US Patent App. 11/728,503, 2007 | 4 | 2007 |
tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10 SE Strassler, IE Bowles, A Krishnamohan, H Kim, CB Edgington, ... Journal of Biological Chemistry 299 (12), 2023 | 2 | 2023 |
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC P Srinivas, M Nosrati, N Zelinskaya, D Dey, LR Comstock, CM Dunham, ... Proceedings of the National Academy of Sciences 120 (25), e2304128120, 2023 | 2 | 2023 |
Evaluation of N‐Mustard Analogues of S‐Adenosyl‐L‐methionine with Eukaryotic DNA Methyltransferase 1 N Sirasunthorn, A Jailwala, A Gerber, LR Comstock ChemistrySelect 4 (35), 10525-10531, 2019 | 2 | 2019 |
Sequence-specific DNA strand scission: evaluation of a methyltransferase-dependent chemoselective ligation LR Comstock The University of Wisconsin-Madison, 2005 | 1 | 2005 |
Modification of cytosine-targeted DNA using novel N-mustard analogs of S-Adenosyl-L-Methionine as DNA methylation probes N Sirasunthorn, L Comstock, A Gerber Abstracts of Papers of the American Chemical Society 256, 2018 | | 2018 |