Ronald A. DePinho
Ronald A. DePinho
MD Anderson
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Cited by
Cited by
Malignant astrocytic glioma: genetics, biology, and paths to treatment
FB Furnari, T Fenton, RM Bachoo, A Mukasa, JM Stommel, A Stegh, ...
Genes & development 21 (21), 2683-2710, 2007
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
MA Blasco, HW Lee, MP Hande, E Samper, PM Lansdorp, RA DePinho, ...
Cell 91 (1), 25-34, 1997
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
TG Boulton, SH Nye, DJ Robbins, NY Ip, E Radzlejewska, ...
Cell 65 (4), 663-675, 1991
Hepatocellular carcinoma pathogenesis: from genes to environment
PA Farazi, RA DePinho
Nature Reviews Cancer 6 (9), 674-687, 2006
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ...
Science 310 (5754), 1642-1646, 2005
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ...
Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
J Pomerantz, N Schreiber-Agus, NJ Liégeois, A Silverman, L Alland, ...
Cell 92 (6), 713-723, 1998
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
Role of the INK4a locus in tumor suppression and cell mortality
M Serrano, HW Lee, L Chin, C Cordon-Cardo, D Beach, RA DePinho
Cell 85 (1), 27-37, 1996
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
JJL Jacobs, K Kieboom, S Marino, RA DePinho, M Van Lohuizen
Nature 397 (6715), 164-168, 1999
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ...
Nature 496 (7443), 101-105, 2013
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Z Tothova, R Kollipara, BJ Huntly, BH Lee, DH Castrillon, DE Cullen, ...
Cell 128 (2), 325-339, 2007
HDAC2 negatively regulates memory formation and synaptic plasticity
JS Guan, SJ Haggarty, E Giacometti, JH Dannenberg, N Joseph, J Gao, ...
Nature 459 (7243), 55-60, 2009
Longevity, stress response, and cancer in aging telomerase-deficient mice
KL Rudolph, S Chang, HW Lee, M Blasco, GJ Gottlieb, C Greider, ...
Cell 96 (5), 701-712, 1999
Pancreatic cancer biology and genetics
N Bardeesy, RA DePinho
Nature Reviews Cancer 2 (12), 897-909, 2002
Essential role of mouse telomerase in highly proliferative organs
HW Lee, MA Blasco, GJ Gottlieb, JW Horner, CW Greider, RA DePinho
Nature 392 (6676), 569-574, 1998
Malignant glioma: genetics and biology of a grave matter
EA Maher, FB Furnari, RM Bachoo, DH Rowitch, DN Louis, WK Cavenee, ...
Genes & development 15 (11), 1311-1333, 2001
Genetics and biology of pancreatic ductal adenocarcinoma
AF Hezel, AC Kimmelman, BZ Stanger, N Bardeesy, RA DePinho
Genes & development 20 (10), 1218-1249, 2006
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
Q Wang, B Hu, X Hu, H Kim, M Squatrito, L Scarpace, AC DeCarvalho, ...
Cancer cell 32 (1), 42-56. e6, 2017
Telomere dysfunction induces metabolic and mitochondrial compromise
E Sahin, S Colla, M Liesa, J Moslehi, FL Müller, M Guo, M Cooper, ...
Nature 470 (7334), 359-365, 2011
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