| High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR RR Ketchem, W Hu, TA Cross Science 261 (5127), 1457-1460, 1993 | 860 | 1993 |
| Four new members expand the interleukin-1 superfamily DE Smith, BR Renshaw, RR Ketchem, M Kubin, KE Garka, JE Sims Journal of Biological Chemistry 275 (2), 1169-1175, 2000 | 420 | 2000 |
| High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints RR Ketchem, B Roux, TA Cross Structure 5 (12), 1655-1669, 1997 | 321 | 1997 |
| Chemical modifications in therapeutic protein aggregates generated under different stress conditions Q Luo, MK Joubert, R Stevenson, RR Ketchem, LO Narhi, J Wypych Journal of Biological Chemistry 286 (28), 25134-25144, 2011 | 222 | 2011 |
| Macromolecular structural elucidation with solid-state NMR-derived orientational constraints RR Ketchem, KC Lee, S Huo, TA Cross Journal of biomolecular NMR 8, 1-14, 1996 | 195 | 1996 |
| The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins M Sastry, RR Ketchem, O Crescenzi, C Weber, MJ Lubienski, H Hidaka, ... Structure 6 (2), 223-231, 1998 | 150 | 1998 |
| ADAM8 as a drug target in pancreatic cancer U Schlomann, G Koller, C Conrad, T Ferdous, P Golfi, AM Garcia, ... Nature communications 6 (1), 6175, 2015 | 148 | 2015 |
| A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1 DE Smith, BP Lipsky, C Russell, RR Ketchem, J Kirchner, K Hensley, ... Immunity 30 (6), 817-831, 2009 | 134 | 2009 |
| A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma D Smith, H Helgason, P Sulem, US Bjornsdottir, AC Lim, ... PLoS genetics 13 (3), e1006659, 2017 | 131 | 2017 |
| Disulfide connectivity of human immunoglobulin G2 structural isoforms T Martinez, A Guo, MJ Allen, M Han, D Pace, J Jones, R Gillespie, ... Biochemistry 47 (28), 7496-7508, 2008 | 110 | 2008 |
| Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies DD Banks, RF Latypov, RR Ketchem, J Woodard, JL Scavezze, CC Siska, ... Journal of pharmaceutical sciences 101 (8), 2720-2732, 2012 | 103 | 2012 |
| Glutamine-linked and non-consensus asparagine-linked oligosaccharides present in human recombinant antibodies define novel protein glycosylation motifs JF Valliere-Douglass, CM Eakin, A Wallace, RR Ketchem, W Wang, ... Journal of Biological Chemistry 285 (21), 16012-16022, 2010 | 103 | 2010 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) SM Jackson, B Shan, W Shen, CT King US Patent 8,168,762, 2012 | 97 | 2012 |
| Monoclonal antibodies to proprotein convertase subtilisin kexin type 9 (PCSK9) SM Jackson, NPC Walker, DE Piper, B Shan, W Shen, JCY Chan, ... US Patent 9,920,134, 2018 | 93* | 2018 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) SM Jackson, NPC Walker, DE Piper, W Shen, CT King, RR Ketchem, ... US Patent 8,563,698, 2013 | 93 | 2013 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) SM Jackson, NPC Walker, DE Piper, B Shan, W Shen, JCY Chan, ... US Patent App. 12/903,084, 2011 | 90 | 2011 |
| Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) SM Jackson, NPC Walker, DE Piper, B Shan, W Shen, JCY Chan, ... US Patent 9,045,547, 2015 | 87 | 2015 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) SM Jackson, NPC Walker, DE Piper, W Shen, CT King, RR Ketchem, ... US Patent 8,829,165, 2014 | 86 | 2014 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) SM Jackson, NPC Walker, DE Piper, B Shan, W Shen, JCY Chan, ... US Patent App. 13/463,751, 2012 | 78 | 2012 |
| Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) SM Jackson, NPC Walker, DE Piper, B Shan, W Shen, JCY Chan, ... US Patent App. 13/252,016, 2012 | 78 | 2012 |
Vladimir RazinkovAmgenVerified email at amgen.com
