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David Heppner
David Heppner
J. Solo Assistant Professor of Medicinal Chemistry, The State University of New York at Buffalo
Verified email at buffalo.edu - Homepage
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Cited by
Cited by
Year
Copper active sites in biology
EI Solomon, DE Heppner, EM Johnston, JW Ginsbach, J Cirera, ...
Chemical reviews 114 (7), 3659-3853, 2014
15442014
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
2592020
Single and dual targeting of mutant EGFR with an allosteric inhibitor
C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ...
Cancer discovery 9 (7), 926-943, 2019
2432019
Copper dioxygen (bio) inorganic chemistry
EI Solomon, JW Ginsbach, DE Heppner, MT Kieber-Emmons, ...
Faraday discussions 148, 11-39, 2011
1932011
Reaction coordinate of a functional model of tyrosinase: spectroscopic and computational characterization
BT Op’t Holt, MA Vance, LM Mirica, DE Heppner, TDP Stack, EI Solomon
Journal of the American Chemical Society 131 (18), 6421-6438, 2009
1242009
Direct cysteine sulfenylation drives activation of the Src kinase
DE Heppner, CM Dustin, C Liao, M Hristova, C Veith, AC Little, BA Ahlers, ...
Nature communications 9 (1), 4522, 2018
1082018
Redox-dependent regulation of epidermal growth factor receptor signaling
DE Heppner, A van der Vliet
Redox Biology 8, 24-27, 2016
782016
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma
A Habibovic, M Hristova, DE Heppner, K Danyal, JL Ather, ...
JCI insight 1 (18), 2016
772016
Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?
DE Heppner, M Hristova, T Ida, A Mijuskovic, CM Dustin, V Bogdándi, ...
Redox biology 14, 379-385, 2018
722018
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
C To, TS Beyett, J Jang, WW Feng, M Bahcall, HM Haikala, BH Shin, ...
Nature Cancer 3 (4), 402-417, 2022
702022
Dual oxidase: a novel therapeutic target in allergic disease
A van der Vliet, K Danyal, DE Heppner
British journal of pharmacology 175 (9), 1401-1418, 2018
622018
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties
AC Little, D Sham, M Hristova, K Danyal, DE Heppner, RA Bauer, ...
Oncogenesis, e261, 2016
622016
The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling
DE Heppner, M Hristova, CM Dustin, K Danyal, A Habibovic, ...
Journal of Biological Chemistry 291 (44), 23282, 2016
602016
Mechanism of the reduction of the native intermediate in the multicopper oxidases: Insights into rapid intramolecular electron transfer in turnover
DE Heppner, CH Kjaergaard, EI Solomon
Journal of the American Chemical Society 136 (51), 17788-17801, 2014
602014
Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DJH De Clercq, DE Heppner, C To, J Jang, E Park, CH Yun, ...
ACS Medicinal Chemistry Letters 10 (11), 1549-1553, 2019
582019
The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies
DE Heppner, YMW Janssen-Heininger, A van der Vliet
Archives of Biochemistry and Biophysics 616, 40-46, 2017
542017
Models for dioxygen activation by the CuB site of dopamine β-monooxygenase and peptidylglycine α-hydroxylating monooxygenase
BF Gherman, DE Heppner, WB Tolman, CJ Cramer
JBIC Journal of Biological Inorganic Chemistry 11, 197-205, 2006
542006
Redox regulation of tyrosine kinase signalling: more than meets the eye
CM Dustin, DE Heppner, MCJ Lin, A van der Vliet
The Journal of Biochemistry 167 (2), 151-163, 2020
522020
Molecular origin of rapid versus slow intramolecular electron transfer in the catalytic cycle of the multicopper oxidases
DE Heppner, CH Kjaergaard, EI Solomon
Journal of the American Chemical Society 135 (33), 12212-12215, 2013
502013
Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics
N Chamberlain, BR Korwin-Mihavics, EM Nakada, SR Bruno, ...
Redox biology 22, 101129, 2019
462019
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